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Abstract The rising prevalence of metabolic syndrome (MetS) and gestational diabetes mellitus (GDM) in women of reproductive age highlights their growing susceptibility to future cardiometabolic diseases. Both conditions signal early metabolic dysfunction tied to abdominal adiposity. We investigated whether relative abdominal adipose tissue (AAT) distribution characterises metabolic risk beyond general adiposity.
Objective To identify systolic blood pressure (SBP) percentile trajectories in children and to describe the early-life risk factors and cardiometabolic correlates of those trajectories. Study design Using age-, sex-, and height-specific SBP percentiles based on the American Academy of Pediatrics reference, we examined SBP trajectories using latent class mixed models from ages 3 to 8 years (n=844) from the GUSTO-study, a Singaporean mother-offspring cohort study.
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