Navnit Singh

Abstract DNA modifications drive aging, neurodegeneration, carcinogenesis and chemotherapy drug action. Accurate mapping of diverse DNA modifications with single-nucleotide precision in complex genomes remains challenging. We upgraded click-code-seq, a click-chemistry-aided DNA-modification mapping strategy, to enable its first application for sequencing oxidation and depurination in the human genome.

Abstract Ultraviolet (UV) radiation from the sun causes adverse skin changes such as premature aging. UVA radiation is the primary factor for photoaging due to its deep penetration into the dermis, and UV-induced mitochondrial DNA (mtDNA) alterations, including deletions, contribute to photoaging and cellular dysfunction. The most frequent mtDNA rearrangement is the common deletion (CD), characterized by the loss of nearly one-third of the genome, 4,977 base pairs.

The Indian EV industry is predicted to reach $113.99 billion by 2029, at a compound annual growth rate of 66.52 percent as per a report published under India Electric Vehicle Market Share & Forecast Analysis, 2029. The major drivers of growth in 2023 will be changes in government policies, the manufacture of batteries at a reasonable price, and infrastructural expansion.