Naxi Tian

Abstract Natural antisense transcripts (NATs) are important spatial and temporal regulators of gene expression. We previously cloned a NAT (Nat9a) to Scn9a, which encodes the NaV1.7 voltage-gated sodium channel that is essential for pain perception. By studying a novel Nat9a global knockout mouse model, we demonstrate that the deletion of Nat9a does not affect pain sensitivity but instead partially impairs motor coordination.

Abstract Genetic deletion and pharmacological inhibition are distinct approaches to unravelling pain mechanisms, identifying targets and developing new analgesics. Both approaches have been applied to the voltage-gated sodium channels Nav1.7 and Nav1.8. Genetic deletion of Nav1.8 in mice leads to a loss of pain, and antagonists are effective human analgesics.

Summary With the current explosion of data volume and the rapid development of cloud computing, cloud storage is one of the most important services of cloud computing. It greatly reduces the cost of users and improves the convenience of use, but the separation of data control and ownership has led to a series of security problems. This article proposes a fine-grained assured deletion scheme based on onion encryption (ADOE) to ensure the security of user data and achieve assured deletion of data.