Nazifa Salsabeel on Muck Rack

Nazifa Salsabeel

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Articles

ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity

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By Weiran Feng, Erik Ladewig, Nazifa Salsabeel, Huiyong Zhao
| biorxiv.org
Abstract To gain insight into how ERG translocations cause prostate cancer, we performed single cell transcriptional profiling of an autochthonous mouse model at an early stage of disease initiation. Despite broad expression of ERG in all prostate epithelial cells, proliferation was enriched in a small, stem-like population with mixed-luminal basal identity (called intermediate cells).
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ERG-driven prostate cancer emerges from basal-luminal hybrid cells

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By Weiran Feng, Erik Ladewig, Nazifa Salsabeel, Huiyong Zhao
| biorxiv.org
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