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Nazim A. Belabbaci on Muck Rack

Nazim A. Belabbaci

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Open chromatin-guided interpretable machine learning reveals cancer-specific chromatin features in cell-free DNA - Communications Biology

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By Sakuntha D. Gunarathna, Nazim A. Belabbaci, Bappa Ghosh, Xusheng Wang
| Nature Verified
Abstract Cell-free DNAs (cfDNAs) are DNA fragments found in blood, originating mainly from immune cells in healthy individuals and from both immune and cancer cells in cancer patients. While cancer-derived cfDNAs carry mutations, they also retain epigenetic features such as DNA methylation and nucleosome positioning. In this study, we examine nucleosome enrichment patterns in cfDNAs from breast and pancreatic cancer patients and find significant enrichment at open chromatin regions.
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