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A Cross Sectional and Longitudinal Assessment of Neuropsychiatric Symptoms and Brain Functional Connectivity in Patients With Mild Cognitive Impairment, Cerebrovascular Disease and Parkinson Disease
NPS such as nighttime behavior, appetite changes, and disinhibition were linked to specific FC patterns in the DMN, ECN, and SN across MCI, CVD, and PD. MCI and PD showed positive FC–NPS correlations, particularly for nighttime behavior, while CVD exhibited negative associations, especially with anxiety and agitation. PD medication reversed the FC–NPS relationship, while no effects were observed in MCI. Most CVD participants were not on CNS medications, limiting conclusions.
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