1. Major adverse cardiovascular and cerebrovascular events were significantly reduced with clopidogrel compared to aspirin alone. 2. There was no significant difference between groups regarding risk of bleeding. Evidence Rating Level: 1 (Excellent) Study Rundown: Aspirin has been recommended to be used indefinitely in patients with coronary artery disease (CAD). However, the comparative efficacy of clopidogrel versus aspirin monotherapy has not been fully evaluated.