Negeen Halabian

Abstract Systematic Review We conducted a systematic review to analyse temporal trends in the epidemiology of traumatic spinal cord injury (SCI) with a focus on patient age, SCI etiology, and baseline severity of SCI. Five databases were searched without any restriction of date, language, or region of publication. 27 studies were included in the final analyses spanning the years 1943–2022, conducted across Europe, North America, and Asia.

Abstract Background: The COVID-19 pandemic has focused research on the detrimental impact of neuroinvasive single-strand RNA (ssRNA) viruses. Those viruses cause a wide range of human diseases ranging from mild to severe life-threatening conditions, and host factors such as age, sex, and the expression of virus receptors can influence the severity of the infection.

Abstract Viral infection severity often varies with host factors such as age and sex. The pathogenesis of infections caused by a broad range of viruses, from neurotropic viruses like Rabies and Zika to respiratory viruses such as influenza and SARS-CoV-2, differ between the sexes and across the lifespan. Typically, older males are more susceptible to severe acute outcomes, while females are more vulnerable to the post-acute sequelae of infections.