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Neha Pincha on Muck Rack

Neha Pincha

As seen in: BioRxiv
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Articles

Angiopoietin-like protein 2 mediates vasculopathy driven fibrogenesis in a mouse model of systemic sclerosis

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By Dyuti Saha, Ravi Kiran Verified, Sujaya Thannimangalath, Neha Pincha
| BioRxiv
Abstract Vasculopathy is a common hallmark of various fibrotic disorders including systemic sclerosis (SSc), yet its underlying etiology and contribution to fibrogenesis remain ill-defined. In SSc the vasculopathy typically precedes the onset of fibrosis and we observed that this phenomenon is recapitulated in the Snail transgenic mouse model of SSc. The vascular anomalies manifest as deformed vessels, endothelial cell dysfunction and vascular leakage.
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