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Articles by Neil Justin
G4 RNA inhibits PRC2 by sequestering two disordered loops required for nucleosome binding
Abstract The chromatin modifier Polycomb Repressive Complex (PRC2) is a key regulator of gene expression that is itself subject to multiple layers of regulation. One mode of PRC2 regulation is its inhibition by G-quadruplex (G4) RNA but the molecular details of this mechanism remain poorly defined. To address this, we solved the structure of the PRC2 catalytic core bound to G4 RNA.
Actor David Rysdahl is getting his big break in the new hit show 'Alien: Earth'
David Rysdahl and Zazie Beetz attend the "Alien: Earth" European Premiere at the Barbican Centre on July 29, 2025 in London, England. Jeff Spicer/Getty Images David Rysdahl’s biggest TV roles, a car salesman with an enigmatic wife in the fifth season of “Fargo,” and a brilliant technician in the hit “Alien: Earth,” have a few things in common. Both characters are moral compasses who are tougher than they first appear. But the most important thread may be the shows’ creator Noah Hawley.
Handicapping the Emmys: Who should win? Who will win?
Zendaya in ‘Euphoria.’ Photo: HBO, HO / TNS Get ready to see some familiar faces on the podium. The 74th annual Primetime Emmy Awards, airing at 7 p.m. Sept. 12 on NBC, may have invited some newcomers to the party, but viewers can expect lots of repeat winners. Host Kenan Thompson will do his best to keep audiences entertained but viewership has decreased steadily in recent years. The reason the Television Academy moved the event to Monday is so it doesn’t have to compete with Sunday football.
5 shows to watch: Fans of 'Toy Story' and Tim Burton need to find 'Lost Ollie'
Minnesota Star Tribune ‘Lost Ollie’ There’s a lot to love about this four-part series, especially when director Peter Ramsey (“Spider-Man: Into the Spider-Verse”) cuts away from the human actors and focuses on his three animated toys, hitting the road to find acceptance. Each has its own tragic back story, but the most heartbreaking one belongs to Zozo, a disturbed carnival-booth clown voiced by Tim Blake Nelson.
5 shows to watch: The great Anne Heche performance you probably don't know about
Minnesota Star Tribune ‘Gracie’s Choice’ In the early 2000s, Anne Heche’s movie career had stalled. Instead of wallowing, the actor turned to stage and TV. In 2004, she earned high praise for her performance in Broadway’s “Twentieth Century” and earned an Emmy nomination for her role as an unhinged, drug-addicted mother in this Lifetime movie. Kristen Bell, who was about to star in “Veronica Mars,” is the lead character, fighting to keep her family together while mom is out carousing.
5 shows to watch: 'A League of Their Own' TV series pitches a whole new ballgame
‘A League of Their Own’ This eight-part series makes a couple of nods to the beloved 1992 film, including a Rosie O’Donnell cameo and a twist on the immortal line about no crying in baseball. But creators Abbi Jacobson and Will Graham have a more ambitious game plan. Jacobson, one-half of the “Broad City” team, plays a small-town catcher who must confront her own racial prejudices and sexual orientation as she tries to lead her Rockford Peaches to a championship.
5 shows to watch: Thrilling and inspiring 'Thirteen Lives' is Ron Howard's best movie in years
‘Thirteen Lives’ Raise your hands if you thought Ron Howard still had a good movie left in him. Actually, “Thirteen Lives” is great in its matter-of-fact, day-by-day account of the 2018 efforts to rescue 12 kids and their soccer coach, trapped in a Thai cave because of a freak flood.
Comment on “Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2”
AbstractJiao and Liu (Research Articles, 16 October 2015, aac4383) reported the crystal structure of the protein complex polycomb repressive complex 2 from Chaetomium thermophilum. This landmark structure has brought invaluable insights into the activation mechanism of this essential methyltransferase. However, the analysis of the x-ray data discussed below suggests that the description of oncogenic H3K27M peptide binding to the active site is incorrect.
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