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Neilesh Soneji

As seen in: JAMA Psychiatry
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Articles

Serial Ketamine Infusions for Treatment-Resistant Bipolar Depression : A Randomized Clinical Trial

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By Diana K. Orsini, Sara Di Luch, George Tomlinson, Nelson Rodrigues, Danica Johnson, Alastair Flint, Cristian-Daniel Llach, Roger S. McIntyre, Rodrigo B. Mansur, Keyvan Karkouti, Amer Burhan, Erica Kaczmarek, Noah Chisamore, Anuj Bhatia Verified, Neilesh Soneji, Deep Grewal, Rachel Laframboise, Joshua Rosenblat, Gabrielle F. M. Lovell, Shreya Vasudeva, Anahita Joshi
| JAMA Psychiatry Verified
Key Points Question Is adjunctive intravenous (IV) ketamine safe and efficacious for treatment-resistant bipolar I or II depression (TRBD)? Findings In this randomized clinical trial, 68 participants with TRBD were randomized to receive 4 ketamine or midazolam infusions over 2 weeks.
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Persistent Opioid Use After Major Surgery-Reply

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By Neilesh Soneji
| JAMA (The Journal of the American Medical Association) Verified
In Reply Ruan and colleagues raise several important issues regarding our recent research letter,1 namely the definition of persistent postoperative opioid use, the extent to which these results differ from the related literature,2- 4 and the potential for patients having received opioid prescriptions from health care professionals other than their surgeons.
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Risks of Developing Persistent Opioid Use After Major Surgery

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By Neilesh Soneji
| JAMA (The Journal of the American Medical Association) Verified
Exposure to opioids is largely unavoidable after major surgery because they are routinely used to treat postoperative pain. Nonetheless, continued long-term opioid use has negative health consequences including opioid dependence.1 Patients and health care professionals are therefore concerned about long-term postoperative opioid use.2 There are limited data on the risk of previously opioid-naive individuals developing persistent postoperative opioid use.
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