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Nejmeh Mashhour

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Articles

The gut-brain vagal axis governs mesolimbic dopamine dynamics and reward events

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By Peter Sheridan Dodds, Valdemar Priebe, Mohammad A Saad, Oriane Onimus, Faustine Arrivet, Tinaig Le Borgne, Sylvie Perez, Sylvie Pérez, Julien Castel, Anthony Ansoult, Benoît Bertrand, Nejmeh Mashhour, Camille de Almeida, Linh-Chi Bui, Marie Vandecasteele, Serge Luquet, Laurent Venance, Nicolas Heck, Fabio Marti, Giuseppe Gangarossa
| Science Magazine Verified
Abstract Reward processes have traditionally been ascribed to dopamine (DA)–associated circuits. While external stimuli, such as food and drugs of abuse, are activators of DA-neuron activity, growing evidence indicates that interoceptive signals also play a critical role. Among these, the gut-brain vagal axis has emerged as a key regulator, although its precise contribution to mesolimbic DA signaling and behavior remains unclear.
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