Nerve-Muscle Unit

ATTRv hereditary transthyretin amyloidosis BMI body mass index CADT Compound Autonomic Dysfunction Test CMAP compound muscle action potential ESC electrochemical skin conductance FAP familial amyloid polyneuropathy GFAP glial fibrillary acidic protein HC healthy controls NCS nerve conduction studies NfL neurofilament light chain NIS Neuropathy Impairment Score NIS-LL NIS lower limb NIS-UL NIS upper limb PND Polyneuropathy Disability Score QOL-DN Norfolk Quality of Life in Diabetic Neuropathy...

Muscle diseases cover a diverse group of disorders that, in most cases, are hereditary. The rarity of the individual muscle diseases provides a challenge for researchers when wanting to establish natural history of the conditions and when trying to develop diagnostic tools, therapies, and outcome measures to evaluate disease progression.

Abstract As the most frequent cause of acquired myopathy, toxic myopathies are characterised by clinicopathological features that vary depending on the mode of action of the drugs or toxins involved. Although a large number of substances can induce myotoxicity, the main culprits are statins, alcohol, and corticosteroids. A rigorous, well-organised diagnostic approach is necessary to obtain a rapid diagnosis.