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Better Late Than Never: The Impact of Steroidal Treatment on the Outcome of Melanoma Patients Treated with Immunotherapy
4. Discussion Allowing the immune system to re-activate and regain dominance over tumor progression, immunotherapy has changed the prognosis of countless patients in an unprecedented way. This unique mechanism of action can, however, result in a loss of self-tolerance and the subsequent development of irAEs. The incidence and the severity of irAE varies, depending on the type of immunotherapy used, and can vary from mild skin rashes to life-threatening conditions such as colitis and hepatitis.
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