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Netanya Bernitz on Muck Rack

Netanya Bernitz

As seen in: BioRxiv
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Articles

The essential host genome for Cryptosporidium intracellular survival exposes metabolic dependencies that can be leveraged for treatment

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By N. Bishara Marzook, Ok-Ryul Song, Lotta Baumgartel, Netanya Bernitz
| BioRxiv
Abstract Mapping how pathogens interact with their host cells can reveal unexpected pathogen and host cell biology, paving the way for new treatments. Cryptosporidium is an intracellular parasite of intestinal epithelial cells, and a leading cause of diarrheal death and disease in infants worldwide. Despite this, very little is known about the cell biology of infection of this eukaryotic pathogen.
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Targeted CRISPR Screens Reveal Genes Essential for Cryptosporidium Survival in the Host Intestine

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By Lucy Watson, Katarzyna A. Sala, Netanya Bernitz, Lotta Baumgartel
| BioRxiv
Abstract The Cryptosporidium parasite is one of the leading causes of diarrheal morbidity and mortality in children, and adolescent infections are associated with chronic malnutrition. There are no vaccines available for protection and only one drug approved for treatment that has limited efficacy. A major barrier to developing new therapeutics is a lack of foundational knowledge of Cryptosporidium biology, including which parasite genes are essential for survival and virulence.
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