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Stacked hydrogel-based brain-on-chips utilizing capillary force flow pinning

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By van Venrooij, Gottlieb S. Oehrlein, A. S. Stodolna, Neuro-Nanoscale Engineering
| aip.org
The brain, as the most intricate organ in the human body,1 characterized by a complex layered architecture,2 structural heterogeneity, and regional stiffness variation.3–5 These features underpin its functional capabilities. In vivo cellular processes such as migration, proliferation, morphology, and differentiation are shaped by mechanical cues,6,7 highlighting the crucial interplay between the structure and function in brain tissue.
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