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Neuromodulatory Circuits

As seen in: Wiley Online Library, BioRxiv
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Articles

Uncovering Hidden Phenotypes in NEX-Cre Mice: Behavioral and Cellular Alterations Demand Re-Evaluation of a Widely Used Transgenic Line

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By Kim Renken, Olivia Andrea Masseck, Neuromodulatory Circuits
| Wiley Online Library Verified
bHLH basic Helix-loop-Helic BLA basolateral amygdala CA1 Cornu ammonis 1 CNS central nervous system CPu caudate putamen Cre Cre Recombinase EPM elevated plus maze LSD dorsal lateral septum LSO intermediate lateral septum mPFC medial prefrontal cortex NaC nucleus accumbens core region NEX NeuroD6 NSFT novelty suppressed feeding test OFT openfield test PCA principal component analysis SHAP SHapley Additive exPlanations SI social interaction SPT sucrose preference test SVM support vector machine...
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Uncovering Hidden Phenotypes in NEX-Cre Mice: Behavioral and Cellular Alterations Demand Re-Evaluation of a Widely Used Transgenic Line

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By Kim Renken, Olivia A Masseck, Neuromodulatory Circuits
| BioRxiv
Abstract Transgenic mouse strains are essential tools in neuroscience, enabling targeted genetic manipulations to investigate brain function and neurological diseases. The NEX-Cre mouse line, which targets glutamatergic principal neurons in the neocortex and hippocampus by expressing Cre-recombinase under the NEX (NeuroD6) promotor, has been widely used for conditional gene manipulation.
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