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Neurophyxia BV

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Articles

Neuroprotection after cardiac arrest with 2-iminobiotin: a single center phase IIa study on safety, tolerability, and pharmacokinetics

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By Amsterdam UMC, Amsterdam Neurosciences, Spyridoula Tsetsou, Neurophyxia BV
| Frontiers
Introduction Out-of-hospital cardiac arrest (OHCA) remains a major cause of death despite improvements such as rapid response teams and the use of automatic external defibrillators. When cardiopulmonary resuscitation is successful, patients are admitted to the intensive care unit (ICU), where the major aim of treatment is to minimize hypoxic–ischemic reperfusion injury. The most recent guidelines advice target temperature management (TTM) besides optimal supportive ICU care (1).
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