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Nevian Brown

As seen in: BioRxiv
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Articles

ENaC contributes to macrophage dysfunction in cystic fibrosis

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By John Moran, Courtney Pugh, Ashley Thomas Verified, Nevian Brown
| BioRxiv
Abstract Background: Cystic fibrosis (CF) is a chronic systemic disease caused by dysfunctional or absent cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is expressed in human immune cells and plays a role in regulating innate immunity both directly and indirectly. Besides CFTR, research indicates that the epithelial sodium channel (ENaC) also contributes to dysfunction in CF airway epithelial cells.
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