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Nexhibe Beciri

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Articles

281 CAR-T-cell monitoring using specific multimers: a fast and specific method allowing uniform evaluation

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By Bjarke Brandt Hansen, Liselotte Brix, Kevin Lenogue, Nexhibe Beciri
| The BMJ Verified
Abstract Background Chimeric antigen receptor (CAR)-T cell therapy is a revolutionary new pillar in cancer treatment. In research CAR-T-cells are often detected through tags added to the CAR construct. However, these methods lack sensitivity and often do not address CAR receptors recognition of its target. Detection methods using the targeted ligand (ie: CD19 + fluorescent antibody) exist but they are indirect and laborious.
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