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Neza Leskovar on Muck Rack

Neza Leskovar

As seen in: BioRxiv
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Articles

EndoNB: A general strategy to study the internalization of cell surface proteins

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By An-Sofie Lenaerts, Jekaterina Krishtal, Tai Arima, Neza Leskovar
| BioRxiv
Abstract The cell surface harbors thousands of distinct proteins whose function depend on continuous cycles of internalization and replenishment. Disturbances in this turnover are typical hallmarks of many diseases. Yet, tools to study the dynamics of most surface proteins are suboptimal or unavailable. Here, we present a new method that enables the analysis of surface protein turnover of virtually any surface protein at endogenous levels.
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