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Ngan Yin Chan on Muck Rack

Ngan Yin Chan

As seen in: Color Research & Application, Nature, Wiley Online Library, PLOS, MDPI, Taylor & Francis Online, Pediatrics, Neurology, Dialnet - Universidad de La Rioja
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Articles

Gut Microbiome in Depression with and without REM Sleep Behavior Disorder

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By Yuhua Yang, Ningning Li, Li Zhou Verified, Siyi Gong, Zhixuan He, Shi Tang, Jianzhang Ni, Yaping Liu, Joey Chan, Siu Ping Lam, Jihui Zhang, Zigui Chen, Vincent C. T. Mok, Ngan Yin Chan, Steven W. H. Chau, Christopher Lai Verified, Filip Scheperjans, Jing L. Wang, Bei Ling Huang, Yun Kwok Wing, Brian P. N. Or, Paul K. S. Chan
| Nature Verified
Abstract Major depressive disorder (MDD) is a risk factor for neurodegeneration, yet its heterogeneity makes identifying at-risk subtype challenging. Notably, MDD frequently co-occurs with REM sleep behavior disorder (RBD), a specific prodrome of α-synucleinopathy. It remains unclear whether comorbid MDD + RBD reflects a benign antidepressant effect, or higher neurodegenerative risk.
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Multimodal AI for predicting comorbid REM sleep behavior disorder in major depressive disorder

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By Lizhou Fan, Xiang Li, Xinze Wang, Jianzhang Ni, Zhixuan He, Yuhua Yang, Huizi Yu, Zhiying Liang, Shi Tang, Siyi Gong, Ningning Li, Xinxin Lin, Xin Ma, Yaping Liu, Jihui Zhang, Jing L. Wang, Joey Chan, Ngan Yin Chan, Tim Li, Bei Ling Huang, Yun Kwok Wing
| Nature Verified
Abstract REM sleep behavior disorder (RBD) is a robust prodromal marker of α-synucleinopathies: idiopathic RBD carries a 10–15-year phenoconversion risk of 80–90% to Parkinson’s disease (PD) and related disorders. In major depressive disorder (MDD), comorbid RBD marks a subgroup at elevated prodromal PD risk, yet is frequently missed in psychiatric practice. Here, we developed a multimodal AI framework to detect comorbid RBD in MDD.
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Capturing omega sign in the clinical assessment of depression by deep learning

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By Jie Chen, Ngan Yin Chan, Chris Chen, Sijing Chen, Joey Chan, Yaping Liu, Shirley Li Verified, Kwong Sak Leung, Pheng-Ann Heng, Tatia M. C. Lee, Tim Li, Yun-Kwok Wing, Chun-Tung Li, Steven W. H. Chau
| Nature Verified
Abstract The omega sign is a melancholic facial expression, resembling the Greek letter omega “Ω”. To study static omega sign (visible full-blown Ω-shaped or vertical wrinkles at rest) and dynamic omega sign (newly appearing or deepening) with digital assessment for depression via deep learning, subjects with major depressive disorder (MDD) and controls were invited to take neutral photos and videotaped interviews to study the static and dynamic omega sign, respectively.
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