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Nhien T. Lu on Muck Rack

Nhien T. Lu

As seen in: BioRxiv
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Articles

Phage-based microbiome manipulation reveals ecological interactions within gut communities

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By Taylor Nguyen, TAYLOR Nguyễn, Morgan Z. Su, Nhien T. Lu
| BioRxiv
Abstract Mechanistic understanding of gut ecology is limited by the availability of tools for precise manipulation of microbiome composition. Here, we isolate lytic phages to enable targeted removal of gut commensal Escherichia fergusonii (Ef) from complex, undefined stool-derived in vitro communities. A single phage drove resistance without fitness cost in monoculture, but resistant Ef exhibited reduced fitness in communities, enabling expansion of closely related Proteobacteria.
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