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Niamh McCawley on Muck Rack

Niamh McCawley

As seen in: Nature
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Articles

Cell engulfment defines spatially distinct competitive metabolic niches associated with clinical outcomes in colorectal cancer

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By Emir Bozkurt, Batuhan Kisakol, Heiko Düssmann, Federico Lucantoni, Anna M. Sturrock, Mohammadreza Azimi, Sanghee Cho, Elizabeth A. McDonough, Tony O’Grady, John Burke, Deborah A. McNamara, Daniel B. Longley, Fiona Ginty, Jochen H. M. Prehn, Joana Fay, Niamh McCawley
| Nature Verified
Abstract Cell competition is an emerging mechanism in which mammalian tissues maintain homeostasis by eliminating less fit (loser) cells through direct interactions with fitter (winner) neighbouring cells. In cancer, these competitive interactions may drive tumour evolution; however, spatial organisation and clinical relevance of these events remain poorly understood. One mechanism by which winner cells eliminate loser cells is engulfment, resulting in cell-in-cell (CIC) formation.
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