Nian Kee Tan

Biological and Medical Applications of Materials and InterfacesAugust 30, 2024 Nian Kee Tan School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia Hazel Chan School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia Hala Zreiqat School of Biomedical Engineering, The University of Sydney, Sydney, NSW 2006, Australia The University of Sydney Nano Institute, Sydney, NSW 2006, Australia Girish Lakhwani School of Chemistry, The University of Sydney, Sydney, NSW...

Abstract The COVID-19 pandemic has had a devastating impact on global health, highlighting the need to understand how the SARS-CoV-2 virus damages the lungs in order to develop effective treatments. Recent research has shown that patients with COVID-19 experience severe oxidative damage to various biomolecules. We propose that the overproduction of reactive oxygen species (ROS) in SARS-CoV-2 infection involves an interaction between copper ions and the virus's spike protein.

A fluorescent naphthalimide NADH mimic for continuous and reversible sensing of cellular redox state† A fluorescent, naphthalimide-based, NADH mimic has been synthesised as a reversible, biocompatible, “on–off” probe for the detection of changes in intracellular redox environment (both oxidation and reduction). Interconversion was confirmed by means of electrochemistry and also 1H NMR, UV-vis and fluorescence spectroscopy.