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Nianguo Dong

As seen in: Nature, Wiley Online Library, Frontiers in Immunology, MDPI, Canadian Journal of Infectious Diseases & Medical Microbiology, Dove Medical Press, JACC (Journal of the American College of Cardiology), The European Heart Journal Podcast
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Articles

Integrated transcriptomics and proteomics analysis reveal potential target in pediatric primary restrictive cardiomyopathy

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By Jie Liu, Qing Guo, Lin Wang, Jing Cynthia Wu, Zubo Wu, Yanlin Xing, Peng Zhu, Nianguo Dong, Jiawei Shi, Hua Peng, Xihang Fu
| Nature Verified
Abstract The heterogeneous etiology and limited therapeutic options of pediatric restrictive cardiomyopathy (RCM)underscore the urgent need to elucidate its molecular mechanisms and identify potential treatment targets. We performed integrated transcriptomic and proteomic analyses on myocardial tissues from 7 pediatric RCM patients and 3 control donors.
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Visinin-like protein 1 disrupts calcium homeostasis and promotes atrial fibrillation in human and rodent models

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By Ke Xiong, Guanghua Wang, Desheng Li, Zhiwen Chen, Qicheng Zou, Xinrui Zhang, Xuxia Zhao, Yixin Yuan, Hongtao Xu, Yi Liu, Dandan Liang, Li Wang, Bin Zhou, Nianguo Dong, Duanyang Xie, Yi-Han Chen, Beihua Shao, Yanru Dong
| Nature Verified
Abstract Atrial fibrillation (AF), the most prevalent sustained cardiac arrhythmia, is closely linked to disturbed intracellular Ca2+ homeostasis. Visinin-like protein 1 (VILIP-1), newly identified in cardiomyocytes, has been implicated in modulating Ca2+ signaling, yet its role in AF remains undefined.
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Inflammasomes as the molecular hub of cardiovascular-metabolic-immune comorbidity networks

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By Xingyu Qian, Jian Sun, Li Xu, Xingjian Hu, Nianguo Dong, Guangzhou Li
| Frontiers in Immunology
Introduction Cardiovascular diseases, metabolic syndrome, and immune dysfunction constitute an interwoven global public health challenge (1–3). Metabolic syndrome affects roughly one-quarter of adults and is characterized by obesity, insulin resistance, and dyslipidemia (4); these features increase the risk of atherosclerotic cardiovascular disease by about twofold (5).
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