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Nianshan Ji on Muck Rack

Nianshan Ji

As seen in: Frontiers
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Articles

Identification and validation of circadian rhythm and astrocyte-associated diagnostic and therapeutic model for cirrhosis encephalopathy patients via integrative bioinformatic pipelines and in vitro validation

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By Zhiguang Sun, Nianshan Ji, Yiyao Cheng, Yuheng Peng
| Frontiers
Abstract Background: Cirrhosis encephalopathy (CE) is a severe neuropsychiatric complication of liver cirrhosis, characterized by cognitive decline. While circadian rhythm (CR) disruption and astrocyte dysfunction are independently implicated, their integrated role in CE pathogenesis remains elusive. Methods: Limma and WGCNA analysis were performed for identification of CR and astrocyte (CA)-associated DEGs in CE patient bulk data (GSE41919 and GSE53808).
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