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Nianyin Lv

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Articles

Age-associated decline of Lamtor5 drives immunosenescence and systemic aging via cGAS-mediated paracrine inflammation

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By Yunzhe Tang, Wei Zhang, Qimeng Zhang, Hairui Zhang, Shumao Cui, Liyun Shi, Nianyin Lv, Hainv Gao, Sergei Krasny
| Nature Verified
Abstract Despite emerging evidences showing the close link between immunosenescence and organismal aging, whether and how aged innate immune system drives systemic aging remains an enigma, and importantly, how primary senescence is initiated and regulated needs to be addressed. Herein we identified late endosomal/lysosomal adapter, MAPK and mTOR activator 5 (Lamtor5) as an age-dependent factor that controlled macrophage senescence and peripheral aging.
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