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Articles by Nicholas DeVito
Remembering John V. Fleming *63
Welcome to the PAW Memorials podcast, where we celebrate the lives of a Princeton University community member. For this episode, PAW Memorials editor Nicholas DeVito sat down with Elyse Graham ’07 to discuss John V. Fleming *63, a 1963 Princeton graduate alumnus in medieval studies. He joined the Princeton faculty in 1965 and transferred to emeritus status in 2006. During his 40 years at Princeton, he was an admired member of the University community.
Open Science Policies and Practices Among Medical Journals
Open Science Policies and Practices Among Medical Journals Supplement 1. eAppendix 1. List and Description of the Items Evaluated by TOP2025 eAppendix 2. Search Strategies, Reviewed by an Information Specialist Following PRESS Guidelines eAppendix 3. Table of the Available Document Types for Each Journal eAppendix 4. Table of the Automatic Tools With the Practices That They Assess eAppendix 5. Detailed Technical Specification and Implementation Procedures for Automated Tools eAppendix 6.
TrialScout links published results to trial registrations using a large language model
1Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden 2UiT the Arctic University of Tromsø, Tromsø, Norway 3TranspariMED, Stockholm, Sweden 4Department of the Psychology of Digitalisation, University of Bern, Bern, Switzerland 5Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, United Kingdom of Great Britain and Northern Ireland (the) 6Center for Pharmacoepidemiology, Division of Clinical...
Data sharing policies, requirements, and support from public and private clinical trial sponsors: a survey on top sponsors of clinical trials in Europe
Original ResearchArticles in Press112452Open access Affiliations & Notes [1]Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail), UMR_S, Rennes, France [2]Institute for Medical Information Processing, Biometry and Epidemiology, Medical Faculty, LMU Munich, Marchioninistr.
An automated approach to improve clinical trial registration and to identify outcome changes on ClinicalTrials.gov
Abstract It is difficult to ensure clinical trial outcomes are defined completely in registrations, and to check outcome changes between registration and posting results. We developed a large language model (LLM)-based approach to evaluate outcome definitions and changes on ClinicalTrials.gov.
What helps and hinders reproducible research? Researchers’ perspectives from a cross-disciplinary interview study
Citation: Kozula M, DeVito NJ, Onghena P, Colombo C, Dudda LA, Muñoz Teno P, et al. (2026) What helps and hinders reproducible research? Researchers’ perspectives from a cross-disciplinary interview study. PLoS One 21(5): e0348512. https://doi.org/10.1371/journal.pone.0348512 Editor: Micah Altman, MIT, UNITED STATES OF AMERICA Received: October 3, 2025; Accepted: April 15, 2026; Published: May 20, 2026 Copyright: © 2026 Kozula et al.
Addressing Common Medications That Influence Immunotherapy Response in Solid Tumors
COMMENTS AND CONTROVERSIES In solid tumor oncology, immunotherapy has demonstrated the ability to cure cancers which previously held a poor prognosis, such as melanoma and microsatellite instability-high colorectal cancer. Progress has slowed because of our inability to fully grasp the myriad of factors that influence immune response in both tumor and host.
Patterns of pre-registration and publication of trials in Cochrane systematic reviews of interventions
Trials are an important form of evidence in scientific literature which are often combined into systematic reviews, which give an overview for the evidence in a specific topic. However, trials and therefore the reviews can be misleading when the authors change the outcomes that they report based on the results they find, which is called reporting bias. One way of minimising reporting bias is to register the planned methods for the trial in advance, known as pre-registration.
Open science interventions to improve reproducibility and replicability of research: a scoping review
The reliability and trustworthiness of research results are in question [1–3]. This is true especially with respect to their reproducibility (defined in this paper as obtaining the same or similar results when rerunning analyses from previous studies using the original design, data and code; cf. [4]) and replicability (defined here as obtaining the same or similar results when repeating, in whole or part, a prior study; cf. [4]).
OpenSAFELY: A platform for analysing electronic health records designed for reproducible research
Key Points Adoption of open working practices that promote reproducibility and transparency of research conducted using electronic health records (EHRs) has been slow. OpenSAFELY is a secure, transparent, open-source software platform designed with reproducibility in mind. It allows secure analysis of pseudonymised primary care data in England in near real-time, resulting in nearly 60 research papers in the four years since its inception.
Gli2 Facilitates Tumor Immune Evasion and Immunotherapeutic Resistance by Coordinating Wnt Ligand and Prostaglandin Signaling
Abstract Therapeutic resistance to immune checkpoint blockade has been commonly linked to the process of mesenchymal transformation (MT) and remains a prevalent obstacle across many cancer types. An improved mechanistic understanding for MT-mediated immune evasion promises to lead to more effective combination therapeutic regimens. Herein, we identify the Hedgehog transcription factor, Gli2, as a key node of tumor-mediated immune evasion and immunotherapy resistance during MT.
Newsmakers Q&A: Stefano Chiazza *13 and Sarah Battat ’17 on Formula 1
When the 2024 Formula 1 season begins this month, two Princeton alumni will be behind the scenes, finding new ways to push the limits of car racing: Stefano Chiazza *13 and Sarah Battat ’17. Both work for the MoneyGram Hass F1 team, Chiazza as the team’s aero performance group team leader and Battat as a junior aerodynamics engineer. The 2024 Formula 1 schedule goes from March through December this year with 24 races in 21 countries.
Results reporting for clinical trials led by medical universities and university hospitals in the Nordic countries was often missing or delayed
Thank you for your interest in spreading the word about medRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from medRxiv Message Body (Your Name) thought you would like to see this page from the medRxiv website.
Improving the transparency and reliability of observational studies through registration
Article Dans Une Revue BMJ - British Medical Journal Année : 2024 Improving the transparency and reliability of observational studies through registration Fichier principal RegistrationOBS_NO_TRACKED_CHANGES.pdf (516.66 Ko) Télécharger le fichier Origine : Fichiers produits par l'(les) auteur(s) Commentaire : ACCEPTED MANUSCRIPT / CLEAN COPY hal-04387187 , version 1 (11-01-2024) Florian Naudet, Chirag Patel, Nicholas Devito, Gérard Le Goff, Ioana Cristea, et al..
Improving the transparency and reliability of observational studies through registration
Florian Naudet, professor of therapeutics1 2, Chirag J Patel, associate professor of biomedical informatics3, Nicholas J DeVito, postdoctoral researcher4, Gérard Le Goff, patient representative5, Ioana A Cristea, associate professor of clinical psychology6, Alain Braillon, retired senior consultant7, Sabine Hoffmann, postdoctoral researcher8 9 1CHU Rennes, Inserm, Institut de Recherche en Santé, Environnement et Travail-UMR_S 1085, University of Rennes, Rennes, France 2Institut Universitaire...
Availability of results of clinical trials registered on EU Clinical Trials Register: cross sectional audit study
Methods This project was preregistered on the Open Science Framework (https://osf.io/drpc5).29 More details on the methods are available in the protocol and on the Open Science Framework. All data collection, preparation, and analyses were conducted in Python 3 (Python Software Foundation) with data and code publicly available from GitHub30; manual data extraction was conducted in Google Forms.
Assessing the utility of molecular diagnostic classification for cancers of unknown primary
1 INTRODUCTION Cancer of unknown primary (CUP) describes a heterogeneous group of metastatic tumors that are defined by the absence of a clinically known tissue of primary origin.
Unlocking Drug Resistance in Multiple Myeloma: Adipocytes as Modulators of Treatment Response
1. Introduction Multiple myeloma (MM) is an incurable hematologic malignancy with nearly 36,000 cases diagnosed in the United States in 2022 [1]. Although overall survival has tripled in recent decades, MM remains an incurable disease with a median life span of 5–8 years, depending on the patient’s age and treatment regimen [2,3]. Obesity, as defined by a body mass index (BMI) ≥ 30 kg/m2, is increasing at an alarming rate in the U.S. [4].
Generative AI for medical research
News & Views Generative AI for...
New UK clinical trials legislation will prioritise transparency
News & Views New UK clinical trials...
Senior Awards Given to the Class of 2023
This year’s top honors at the Princeton Varsity Club senior awards banquet went to Daria Frayman ’23, the Von Kienbusch Award winner, who ranked as high as No. 1 nationally in singles while leading the women’s tennis team to four Ivy League titles and three NCAA Tournament second-round appearances, and Sondre Guttormsen ’23, the Roper Trophy winner, who set program and Ivy pole vaulting records, indoors and outdoors, and won three NCAA titles in his event.
Newsmakers Q&A: Peter Wilson ’66 on Getting Blacklisted by Russia
‘The institutional corruption was far worse, I think, than we imagined or understood,’ Wilson says Courtesy of Peter Wilson ’66 Peter Wilson ’66 is an adjunct senior defense policy analyst at the RAND Corporation think tank who was recently placed on a persona non grata list by Russia and Vladimir Putin. During the last 30 years, Wilson has specialized in strategic planning exercises for the Department of Defense, the CIA, and other agencies.
Increasing the Reporting Quality of Clinical Trials
Increasing the Reporting Quality of Clinical Trials—No Easy Solutions? Peer Review Intervention to Improve Article Adherence to Reporting Guidelines Benjamin Speich, PhD; Erika Mann, BA; Christof M. Schönenberger, MD; Katie Mellor, PhD; Alexandra N. Griessbach, MSc; Paula Dhiman, PhD; Pooja Gandhi, PhD; Szimonetta Lohner, PhD; Arnav Agarwal, MD; Ayodele Odutayo, MD, PhD; Iratxe Puebla, PhD; Alejandra Clark, PhD; An-Wen Chan, MD, DPhil; Michael M.
A SREBF2-dependent gene program drives an immunotolerant dendritic cell population during cancer progression
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
Newsmakers Q&A: Physicist Katherine Freese ’77 on the Dark Big Bang
Katherine Freese ’77, a physicist at the University of Texas, Austin, has proposed that dark matter wasn’t created in the Big Bang along with all other matter, but rather in a second Big Bang some weeks later. Freese, who was recently elected to the National Academy of Sciences and serves as director of the Weinberg Institute for Theoretical Physics, spoke with PAW about the Dark Big Bang theory and what it means for our understanding of the universe. What is dark matter?
Newsmakers Q&A: Opera Singer Anthony Roth Costanzo ’04
Grammy-winning opera singer Anthony Roth Costanzo ’04 will be the featured soloist for the 2023-24 season at the Princeton Symphony Orchestra. PAW spoke with him about coming back to Princeton and what’s next for the countertenor, including the English National Opera and the Metropolitan Opera — and about the recent M&Ms commercial in which he played a singing potted plant. What are you looking forward to this season?
Newsmakers Q&A: Attorney Abby Rubenfeld ’75 Fights Tennessee Drag Ban
Abby Rubenfeld ’75 is a top attorney in the field of LGBTQ family law and civil rights issues who worked on the cases that legalized same-sex marriage. This year she has rallied against lawmakers’ plans in her state, Tennessee, to ban drag shows, and testified before the state legislature on behalf of the Tennessee Pride Chamber, of which she’s a member. The legislation has since passed, and now Rubenfeld is planning to fight it in court. When does the law go into effect?
Newsmakers Q&A: Jay Famiglietti *92 on Cloud Seeding Technology
‘It’s a little bit like trying to squeeze water from a stone’ Jay Famiglietti *92 recently became the global futures professor at Arizona State University’s School of Sustainability. Following this report by The Mercury-News in California, he spoke with PAW about whether cloud seeding could hold the answer to the state’s lack of rainfall and the drying of the Colorado River Basin. Can you explain cloud seeding?
Newsmakers Q&A: Doug Schutte ’75 Is Virginia’s Top Blood Donor
Doug Schutte ’75 recently became the top blood donor in the state of Virginia, according to the American Red Cross. He’s been donating blood products since 1987, and since 1999 he has donated two units of platelets every 14 days and a unit of plasma every 28 days, for a total of 24 donations a year (the most the FDA will allow a person to donate). Schutte’s blood has gone as far south as Atlanta and as far north as Maryland. How did you get started donating blood?
Jan. 24: Jack Finlay ’18 Studies Long COVID and Loss of Smell
John “Jack” Finlay ’18, an M.D. and Ph.D. student at Duke University, recently published a paper in Science Translational Medicine about a frightening facet of long COVID — persistent loss of smell. In a recent interview with PAW, he discussed his findings and whether and how this strange condition might be treated. Note: Scroll down to see the usual list of alumni in the news. What did you study for this paper, and why?
Jan. 18: Mark Herrema ’04 Explains Carbon Capture Technology
Mark Herrema ’04 is co-founder and CEO of Newlight Technologies, which opened in 2020 with a plan to replace plastic with biodegradable materials that actually pull greenhouse gases out of the atmosphere. Herrema spoke recently with The Wall Street Journal about the path companies like his are taking to bring these products into the mainstream marketplace, and in an interview with PAW, he further explained the science behind capturing carbon. How does carbon capture technology work?
Estimating the effect of COVID-19 on trial design characteristics: a registered report
1 In the stage 1 IPA this read ‘heterogeneity’, which was a typo. 2 In the stage 1 IPA this read ‘conditional total effect’. All effects calculated in this paper are conditional, so this word was removed to avoid confusion. 3 Deviation: this data range was expanded during data collection with approval from the editor. This range was chosen to meet the required sample size for the indication matched comparison after false positive terms were excluded.
Dec. 13: Nada Elbuluk ’04 Explains the Skin Condition Vitiligo
Nada Elbuluk ’04 recently spoke with Dermatology Times about vitiligo, an autoimmune disease where antibodies attack melanocytes, the cells that make pigment, leaving white patches on the skin. Celebrities such as Michael Jackson, model Winnie Harlow, and actor Jon Hamm have talked about their experiences with the condition.
The new European CTIS clinical trial registry: first impressions
Europe's new trial registry was intended to provide more transparency about clinical trials and improved user friendliness. Does it deliver? Registry wizard Nicholas DeVito (creator of the EU Trials Tracker) shares his first impressions below. Background The Clinical Trial Information System (CTIS) is the European Union’s new registry set to fully replace the existing EU Clinical Trials Registry next year.
Sharing study materials in health and medical research
http://orcid.org/0000-0001-8286-1995Nicholas J DeVito1, Caroline Morton1, http://orcid.org/0000-0003-4190-7912Aidan Gregory Cashin2,3, http://orcid.org/0000-0003-0244-5620Georgia C Richards4, Hopin Lee5,6 1Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, Oxfordshire, UK 2School of Health Sciences, University of New South Wales, Sydney, New South Wales, Australia 3Centre for Pain IMPACT, Neuroscience Research...
Software development skills for health data researchers
Box 1 Glossary Analytic Script: A series of commands written in a programming or statistical language such as R, Stata or Python, that are executed by a computer. These commands are used to do the analysis and may involve data extraction, cleaning, processing and analysis. Commit: An individual change or revision to a file or set of files9 Docstring: This is a non-executable text that is attached to units of code such as functions, and documents what the code is doing.
New EU trial reporting regulations must be enforced
Intended for healthcare professionals Toggle navigation The BMJ logo Toggle top menu News & Views New EU trial reporting...
Automatic registration for UK trials
Intended for healthcare professionals Toggle navigation The BMJ logo Toggle top menu News & Views Automatic registration...
European non-commercial sponsors showed substantial variation in results reporting to the EU trial registry
To describe the trial results reporting behavior of leading European non-commercial sponsors by country and over time. Cross-sectional analysis describing results reporting rates to the European Clinical Trials Registry among the top sponsors across Europe as of May 2021 and a comparison of reporting trends for a cohort of major sponsors between January 2018 and May 2021.
E-cigarette manufacturers’ compliance with clinical trial reporting expectations: a case series of registered trials by Juul Labs
E-cigarette manufacturers’ compliance with clinical trial reporting expectations: a case series of registered trials by Juul Labs http://orcid.org/0000-0001-8286-1995Nicholas J DeVito1, Henry Drysdale1, Martin McKee2, Ben Goldacre1 1Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK 2Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK Correspondence to Nicholas J DeVito, Nuffield Department of Primary...
Evaluation of Compliance With Legal Requirements Under the FDA Amendments Act of 2007 for Timely Registration of Clinical Trials, Data Verification, Delayed Reporting, and Trial Document Submission | Medical Journals and Publishing | JAMA Internal Medicin
The US Food and Drug Administration (FDA) Amendments Act of 2007 (FDAAA 2007), as further clarified by regulations effective in 2017 (the Final Rule), requires sponsors of clinical trials covered by the legal requirements to register and report clinical trials to ClinicalTrials.gov.1 In a previous report,2 we assessed compliance with the legal requirement to report clinical trial results; 1722 of 4209 trials (40.9%) due to report results did so within the 1-year deadline.
Pharmacological Wnt ligand inhibition overcomes key tumor-mediated resistance pathways to anti-PD-1 immunotherapy
Highlights • Proximal Wnt ligand signaling activity is associated with anti-PD-1 resistance • Wnt signaling drives kynurenine production and PMN-MDSC accumulation in tumors • Wnt ligand inhibition enhances the efficacy of PD-1 blockade in transgenic models • Wnt inhibition creates a more favorable immune microenvironment in cancer patients Summary While immune checkpoint blockade is associated with prolonged responses in multiple cancers, most patients still do not benefit from this...
Reducing bias and improving transparency in medical research: a critical overview of the problems, progress and suggested next steps
Existing measures addressing problems in medical research Several measures have been introduced to improve the reproducibility and transparency of medical research. Although no individual measure would be a cure-all, many successes have been documented. These highlighted achievements demonstrate that coordinated action to improve the research landscape is possible and necessary.
Clinical trial reporting - Authors' reply
We thank Liang Gao and colleagues for sharing their examination of the Chinese Clinical Trial Registry. It is disappointing that trial results are rarely shared on this registry. Earlier this year, we reported technical difficulties in accessing results on the Chinese Clinical Trial Registry in a presentation at the REWARD–EQUATOR 2020 conference, as part of our ongoing work examining clinical trial registries. 1 DeVito NJ Results reporting on ICTRP registries: a cross-sectional audit study.
Hydroxychloroquine for prevention of COVID-19 mortality: a population-based cohort study
Abstract Background. Hydroxychloroquine has been shown to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro, but early clinical studies found no benefit treating patients with coronavirus disease 2019 (COVID-19). We set out to evaluate the effectiveness of hydroxychloroquine for prevention, as opposed to treatment, of COVID-19 mortality. Methods.
How we learnt to stop worrying and love web scraping
Build your own webscraping tool to step up your online research.Credit: Shutterstock In research, time and resources are precious. Automating common tasks, such as data collection, can make a project efficient and repeatable, leading in turn to increased productivity and output. You will end up with a shareble and reproducible method for data collection that can be verified, used and expanded on by others — in other words, a computationally reproducible data-collection workflow.
Rapid Results Dissemination of Registered COVID-19 Clinical Trials
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Effect of pre-exposure use of hydroxychloroquine on COVID-19 mortality: a population-based cohort study in patients with rheumatoid arthritis or systemic lupus erythematosus using the OpenSAFELY platform
Summary Background Hydroxychloroquine has been shown to inhibit entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into epithelial cells in vitro, but clinical studies found no evidence of reduced mortality when treating patients with COVID-19. We aimed to evaluate the effectiveness of hydroxychloroquine for prevention of COVID-19 mortality, as opposed to treatment for the disease.
Compliance with legal requirement to report clinical trial results on ClinicalTrials.gov: a cohort study
Summary Background Failure to report the results of a clinical trial can distort the evidence base for clinical practice, breaches researchers' ethical obligations to participants, and represents an important source of research waste. The Food and Drug Administration Amendments Act (FDAAA) of 2007 now requires sponsors of applicable trials to report their results directly onto ClinicalTrials.gov within 1 year of completion.
Why researchers should share their analytic code
News & Views Why researchers should...
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