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Nickens Dana

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Articles

Population modeling analyses of crizotinib in pediatric patients with ALK‐positive advanced cancers

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By Frank M. Balis, Li Jerry, Lin Swan, Nickens Dana
| Wiley Online Library Verified
Background Alterations in the ALK (anaplastic lymphoma kinase) gene play a critical role in pathogenesis of anaplastic large cell lymphoma (ALCL). Crizotinib is a small molecule competitive inhibitor of ALK, ROS1, and MET kinases and was approved for pediatric patients with ALK-positive relapsed or refractory, systemic ALCL, and ALK-positive unresectable, recurrent, or refractory inflammatory myofibroblastic tumors (IMT).
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