Nickesha C. Anderson on Muck Rack

Nickesha C. Anderson

As seen in: Stem Cell Reports
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Articles

Excitatory Cortical Neurons from CDKL5 Deficiency Disorder Patient-Derived Organoids Show Early Hyperexcitability Not Identified in Neurogenin2 Induced Neurons

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By Madison R. Glass, Dosh Whye, Nickesha C. Anderson
| biorxiv.org
Abstract CDKL5 deficiency disorder (CDD) is a rare developmental and epileptic encephalopathy resulting from variants in cyclin-dependent kinase-like 5 (CDKL5) that lead to impaired kinase activity or loss of function. CDD is one of the most common genetic etiologies identified in epilepsy cohorts.
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Balancing serendipity and reproducibility: Pluripotent stem cells as experimental systems for intellectual and developmental disorders

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By Kesavan Meganathan, Wardiya Afshar Saber, Nickesha C. Anderson, Pin-Fang Chen
| Stem Cell Reports Verified
Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) and their differentiation into neural lineages is a revolutionary experimental system for studying neurological disorders, including intellectual and developmental disabilities (IDDs). However, issues related to variability and reproducibility have hindered translating preclinical findings into drug discovery.
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