Nickie Chan on Muck Rack

Nickie Chan

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Articles

Gut-derived hyodeoxycholate reprograms the spleen–eye immunometabolic axis to suppress autoimmune uveitis

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By Yitao Li, Weijia Zheng, Jiao Ma, Lu Liu, Xintong Yang, Junliang Kuang, Chengqiang Wang, Aihua Zhao, Ruonan Wang, Xiaojiao Zheng, Gerry Melino, Aiping Lu, Xiaolu Yang, Wei Jia, Nickie Chan
| Nature Verified
Abstract Autoimmune uveitis (AU) lacks targeted therapies beyond immunosuppression. We identified hyodeoxycholate (HDCA), a gut-derived secondary bile acid, as a key immunometabolic regulator in AU. Metabolomics revealed systemic depletion of HDCA and oleic acid (C18:1n9) in AU patients and experimental AU (EAU) mice, correlating with disease severity. HDCA administration effectively attenuated EAU by reducing pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) and elevating IL-10.
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