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Nickolai A. Barlev on Muck Rack

Nickolai A. Barlev

As seen in: MDPI
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p53 Affects Zeb1 Interactome of Breast Cancer Stem Cells

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By Sergey E Parfenyev, Sergey V. Shabelnikov, Elena N. Tolkunova, Nickolai A. Barlev
| MDPI
Abstract : P53 is a critical tumor suppressor that protects the integrity of genome and prevents cells from malignant transformation, including metastases. One of the driving forces behind the onset of metastases is the epithelial to mesenchymal transition (EMT) program. Zeb1 is one of the key transcription factors that govern EMT (TF-EMT). Therefore, the interaction and mutual influence of p53 and Zeb1 plays a critical role in carcinogenesis.
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