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Nico Golfrè Andreasi

As seen in: Nature, Wiley Online Library
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Articles

STN-DBS and LCIG differentially affect long-term axial symptoms in Parkinson’s disease

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By Fabiana Colucci, Ahmet Kaymak, Andrea Gozzi, Antonio Elia, Roberto Cilia, Valentina Leta, Nico Golfrè Andreasi, Grazia Devigili, Francesco Pirone, Alberto Mazzoni, Luigi Michele Romito, Roberto Eleopra, Maura Pugliatti, Mariachiara Sensi, Pietro Antenucci, Arianna Braccia, Gianfranco Gaudiano, Mattia Tosi
| Nature Verified
Abstract Bilateral subthalamic nucleus Deep Brain Stimulation (STN-DBS) and Levodopa-Carbidopa Intestinal Gel (LCIG) represent established treatment options for complicated Parkinson’s disease (PD). Evidence regarding their effectiveness on axial symptoms remains limited, despite disability.
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Genetic Etiology Influences the Low‐Frequency Components of Globus Pallidus Internus Electrophysiology in Dystonia

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By Ahmet Kaymak, Luigi M. Romito, Fabiana Colucci, Nico Golfrè Andreasi
| Wiley Online Library Verified
1 Introduction Dystonia is a movement disorder causing abnormal, often repetitive movements or postures due to muscle contractions, with genetic forms resulting from pathogenic mutations in causative genes leading to diverse clinical presentations [1, 2]. Deep brain stimulation (DBS) targeting the globus pallidus internus (GPi) is an effective therapy for the drug-resistant form of dystonia [3].
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Genome Aggregation Database Version 4-New Challenges of Variant Analysis in Movement Disorders

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By Elisabetta Indelicato, Luigi Michele Romito, Philip Harrer, Nico Golfrè Andreasi
| Wiley Online Library Verified
The occurrence of disease-associated variants in “healthy” controls is a well-established characteristic of inherited movement disorders.1 A typical example of a pathogenic variant found in controls is TOR1A p.Glu303del underlying early-onset dystonia.2 There are several explanations for why variants linked to monogenic movement disorders can be present in catalogs of “normal” genetic variations.
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