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Nicola Mutch

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Articles by Nicola Mutch

Transglutaminase 2 contributes to the blood clotting cascade

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By Mauro Piacentini, Nicola Mutch, Alessandro Mauriello, Manuel Scimeca, Mara Mancini, Valerio Da Ros, Yufang Shi, Eleonora Candi, Zhuo Wang, Martin Griffin, Gerry Melino, Francesco Barilla’
| Nature Verified
Abstract Cross-linking of fibrin and associated proteins via Nε-(γ-glutamyl)lysine bonds in clot formation is a well-established component of the hemodynamic mechanism, providing clot rigidity and reducing the rate of fibrinolysis. The latter effect occurs predominantly through the incorporation of fibrinolytic inhibitors. To date, this function has been attributed exclusively to Factor XIIIa, also known as plasma transglutaminase (TG), one of eight identified in mammals.
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Dr Nicola Mutch | Staff Profile | The Institute of Medical Sciences | The University of Aberdeen

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By Nicola Mutch
| University of Aberdeen
Dr Nicola Mutch BSc (Hons), Molecular and Cellular Biology; PhD, Thrombosis & Haemostasis Reader Overview Dr Nicola Mutch Web Links Honoured to have been interviewed as part of the BHF celebration of Ada Lovelace Day 2015 on the 'Power of women in science' https://www.bhf.org.uk/news-from-the-bhf/news-archive/2015/october/nicola-mutch-interview-ada-lovelace-day Article as part of the series on European Perspectives in Cardiology in Circulation Research on my research in to crosstalk within...
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