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Nicolas Merienne

As seen in: Nature, Cell Press
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Articles by Nicolas Merienne

Single-cell RNA sequencing reveals developmental heterogeneity among Plasmodium berghei sporozoites

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By Anthony A. Ruberto, Nicolas Merienne, Thomas Obadia, Caitlin Bourke
| Nature Verified
Abstract In the malaria-causing parasite’s life cycle, Plasmodium sporozoites must travel from the midgut of a mosquito to the salivary glands before they can infect a mammalian host. However, only a fraction of sporozoites complete the journey. Since salivary gland invasion is required for transmission of sporozoites, insights at the molecular level can contribute to strategies for malaria prevention.
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Cell-Type-Specific Gene Expression Profiling in Adult Mouse Brain Reveals Normal and Disease-State Signatures

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By Nicolas Merienne, Anne Schneider, Cécile Meunier, Adaptive Neuroscience
| Cell Press Verified
Highlights • Optimized LCM method for mouse cell-type-specific dissection • Transcriptomic and network signatures of four adult striatal subpopulations • Role of transcription factors and DNA conformation in cell-type gene enrichment • Cell-type-specific contribution of epigenetic mechanisms in Huntington’ disease Summary The role of brain cell-type-specific functions and profiles in pathological and non-pathological contexts is still poorly defined.
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The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes

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By Nicolas Merienne, Molecular Neurotherapies, Gabriel Vachey, Lucie de Longprez
| Cell Press Verified
We took advantage of the large cloning capacity of lentiviral vectors (LV) and their high transduction efficiencies, safety, and long-term expression in the CNS to optimize the CRISPR/Cas9 system delivery (Cartier et al., 2009xHematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy. Cartier, N., Hacein-Bey-Abina, S., Bartholomae, C.C., Veres, G., Schmidt, M., Kutschera, I., Vidaud, M., Abel, U., Dal-Cortivo, L., Caccavelli, L. et al. Science.
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