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Reading is both an art and a science — and we’ll need to leverage both to make our nation’s young people fall back in love with reading. When I was in school I was a voracious reader. My mom would take my sister and me to the library and I would check a stack of books by authors such as Judy Blume, Beverly Cleary, Roald Dahl, and Gary Paulsen.
Abstract Growth arrest specific 1 (GAS1) is a key regulator of mammalian embryogenesis, best known for its role in Hedgehog (HH) signaling, but with additional described roles in the FGF, RET, and NOTCH pathways. Previous work indicated a later role for GAS1 in kidney development through FGF pathway modulation.
Hedgehog (HH) signaling critically regulates embryonic and postnatal development as well as adult tissue homeostasis, and its perturbation can lead to developmental disorders, birth defects, and cancers. Neuropilins (NRPs), which have well-defined roles in Semaphorin and VEGF signaling, positively regulate HH pathway function, although their mechanism of action in HH signaling remains unclear.
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