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Nicole Ludwig on Muck Rack

Nicole Ludwig

As seen in: Nature, MDPI, JAMA Oncology, Royal Society of Chemistry, BioRxiv, Edutopia, The World Bank Research Observer
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Articles

Extracellular vesicles and their RNA cargo facilitate bidirectional cross-kingdom communication between human and bacterial cells

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By Shusruto Rishik, Nicole Ludwig, Laura Groeger, Amila Beganovic
| BioRxiv
Abstract While extracellular vesicles (EVs) are established mediators of intra-species signaling, their role as active participants in cross-kingdom communication remains incompletely understood. Here, we reveal that human colon cells and both Gram-positive and Gram-negative gut bacteria engage in species-specific, EV-mediated molecular dialogue, driven in part by RNA cargo.
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Spatiotemporal transcriptomic niches of complement pathway and serine protease inhibitor activation in aging and infection

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By Fabian Kern, Viktoria Wagner, Vanessa Wahl, Nicole Ludwig
| BioRxiv
Abstract Aging is a multifactorial and complex physiological process, affecting every organ with characteristic manifestations. Understanding the molecular mechanisms that drive aging processes is crucial to targeting age-related disorders. Recent reports suggest that severe post-infection syndromes can partially accelerate aging. However, the underlying gene-encoded regulatory interplay, whether being shared or distinct between aging and infection biology are poorly understood.
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Quantitative design of cell type-specific mRNA stability from microRNA expression data

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By Lukas Oesinghaus, Sebastian M. Castillo-Hair, Nicole Ludwig, Andreas Keller
| BioRxiv
Abstract Limiting expression to target cell types is a longstanding goal in gene therapy, which could be met by sensing endogenous microRNA. However, an unclear association between microRNA expression and activity currently hampers such an approach. Here, we probe this relationship by measuring the stability of synthetic microRNA-responsive 3'UTRs across 10 cell lines in a library format.
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