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Niculin J Herz on Muck Rack

Niculin J Herz

As seen in: Nature, Texas Medical Center
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Articles

Synergistic role of TFEB/TFE3 and mTORC1 in kidney cystogenesis and tumorigenesis

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By Marco Ferniani, Irene Sambri, Tuong Huynh, Gennaro Tufano, Niculin J Herz, Barbara Rossi, Antonella Iannaccone, Francesco Trepiccione, Alessia Calcagni, Andrea Ballabio, Rossella Pennella
| Nature Verified
Abstract Birt-Hogg-Dubé (BHD) and Tuberous Sclerosis (TSC) are inherited cancer syndromes associated with kidney cystogenesis and tumorigenesis and caused by mutations of the folliculin (FLCN) and TSC1/2 genes, respectively. We and others previously showed that Transcription Factors EB (TFEB) and E3 (TFE3) are the main drivers of the kidney phenotypes observed in mouse models of these conditions.
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"TFEB Regulates Murine Liver Cell Fate During Development and Regenerat" by Nunzia Pastore, Tuong Huynh et al.

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By Nunzia Pastore, Tuong Huynh, Niculin J Herz, Alessia Calcagni'
| Texas Medical Center
Nature Communications 10.1038/s41467-020-16300-x Animals, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Bile Duct Neoplasms, Bile Ducts, Cell Differentiation, Cell Lineage, Cell Proliferation, Cholangiocarcinoma, Down-Regulation, Hepatocytes, Liver, Mice, Inbred C57BL, Mice, Transgenic, Models, Biological, Phenotype, Promoter Regions, Genetic, Protein Binding, Regeneration, SOX9 Transcription Factor, Spheroids, Cellular, Stem Cells, Up-Regulation, Transdifferentiation,...
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