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Nidus Jacobsen

As seen in: Frontiers in Immunology
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Articles

Human CD4 + iNKT cells have highly oxidative metabolism and use glycogen reserves to sustain IFN-γ production in nutrient-limited environments

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By Kelsey Smith, Nikhila S. Bharadwaj, Jenny E. Gumperz, Niharika M. Patankar, Nidus Jacobsen
| Frontiers in Immunology
Abstract Invariant natural killer T (iNKT) cells are promising candidates for allogeneic cellular immunotherapy, but the metabolic pathways that support their effector function in nutrient-limited tumor microenvironments remain poorly defined. Human iNKT cells segregate into CD4+ and CD4⁻CD8⁻ double-negative (DN) subsets with distinct functional profiles, yet whether they use divergent metabolic strategies to sustain IFN-γ production is unknown.
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