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Niedharsan Pooranachandran on Muck Rack

Niedharsan Pooranachandran

As seen in: BioRxiv
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Articles

Pneumolysin-dependent and independent non-canonical autophagy processes mediate host defense against pneumococcal infection

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By Erin Faught, Bartosz J Michno, Niedharsan Pooranachandran, Tonisha C Smith
| BioRxiv
Abstract Streptococcus pneumoniae is an opportunistic pathogen responsible for life-threatening diseases including pneumonia and meningitis. The host defense against pneumococci relies heavily on macrophages, which can effectively internalize and degrade bacteria. Recent studies have implicated both canonical and non-canonical autophagy-related processes in bacterial clearance, but the precise pathways mediating defense against S. pneumoniae remain unknown.
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