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Niera M. S. Niera on Muck Rack

Niera M. S. Niera

As seen in: Nature
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Sacubitril/valsartan attenuates renal injury caused by cecal ligation and puncture via TLR4/NFκB/NLRP3 inhibition and reduced oxidative stress and apoptosis in rats

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By Reham H. Mohyeldin, Mahmoud Abdelnaser, Remon Roshdy Rofaeil, Mina Ezzat Attya, Michael Ayad, Niera M. S. Niera, Ehab E. Sharata
| Nature Verified
Abstract Sepsis constitutes a life-threatening systemic inflammatory response triggered by infection. It remains among the leading causes of in-hospital mortality, claiming over 11 million lives annually. For the first time, this study aimed to evaluate the capacity of sacubitril/valsartan to protect against renal damage induced by cecal ligation and puncture (CLP) in an experimental rat model. The CLP procedure was employed to establish a rat model of sepsis.
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