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Nikitas Melios

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Articles

Comparative Analysis of pH and Target-Induced Conformational Changes of an Oxytetracycline Aptamer in Solution Phase and Surface-Immobilized Form

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By Abdul Shaban, Kristóf Jakab, Nikitas Melios, George Tsekenis
| MDPI
1. Introduction Aptamers are relatively short (~15–75 bases), single-stranded oligonucleotides (DNA or RNA) that bind selectively and with high affinity to their respective targets, against which they are artificially selected through the process of Systematic Evolution of Ligands by Exponential Enrichment (SELEX) [1,2]. During this procedure, a random oligonucleotide library is incubated with the target.
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