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Nikolaos Mitrousis on Muck Rack

Nikolaos Mitrousis

As seen in: Nature, Science Magazine
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Articles

Lymphangiogenesis-inducing vaccines elicit potent and long-lasting T cell immunity against melanomas

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By Maria Stella Sasso, Nikolaos Mitrousis, Yue Wang, Priscilla S. Briquez
| Science Magazine Verified
Abstract In melanoma, the induction of lymphatic growth (lymphangiogenesis) has long been correlated with metastasis and poor prognosis, but we recently showed it can synergistically enhance cancer immunotherapy and boost T cell immunity. Here, we develop a translational approach for exploiting this “lymphangiogenic potentiation” of immunotherapy in a cancer vaccine using lethally irradiated tumor cells overexpressing vascular endothelial growth factor C (VEGF-C) and topical adjuvants.
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Biomaterials for cell transplantation

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By Ana Fokina, Molly Shoichet, Biomedical Engineering, Nikolaos Mitrousis
| Nature Verified
1. Godwin, J. The promise of perfect adult tissue repair and regeneration in mammals: learning from regenerative amphibians and fish. Bioessays 36, 861–871 (2014). 2. Andersson-Rolf, A., Zilbauer, M., Koo, B. K. & Clevers, H. Stem cells in repair of gastrointestinal epithelia. Physiol. (Bethesda) 32, 278–289 (2017). 3. Gonzalez, G., Sasamoto, Y., Ksander, B. R., Frank, M. H. & Frank, N. Y. Limbal stem cells: identity, developmental origin, and therapeutic potential. Wiley Interdiscip. Rev. Dev. Biol.
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