Nikolay Chekanov

Introduction The most common form of adenomatous polyposis syndrome is familial adenomatous polyposis (FAP), (OMIM # 175100) - a hereditary syndrome characterized by dozens to hundreds (and even thousands) of colonic polyps and extremely high risk of colorectal cancer unless the polyps are detected and surgically removed early. The incidence of FAP is between 1 per 5000 and 1 per 18000 cases (1).

Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.

Since the pioneering effort by the HapMap Consortium made in 2003 [4], multiple studies were conducted to investigate human genetic diversity, population structure, migration routes, and genotype-phenotype association [2, 8, 16, 32, 33, 55, 66–75]. These studies produced a variety of computational tools and reference datasets, leaving just a few blind spots.