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Nikolia Darzenta on Muck Rack

Nikolia Darzenta

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Articles

Extracellular vesicles from inflammatory-primed stromal cells reduce in vitro inflammation in Sandhoff disease model

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By Emily Davis, Rie Watanabe, Maria C. Naskou, Nikolia Darzenta, Melikasadat Mollabashi, Savanie Fernando
| Nature Verified
Abstract Sandhoff disease (SD) is a fatal lysosomal storage disorder caused by β-N-acetylhexosaminidase deficiency, resulting in GM2 ganglioside accumulation, severe neurodegeneration, and chronic neuroinflammation. While enzyme-restoring therapies, such as AAV gene transfer, effectively target the primary enzymatic deficit, neuroinflammation persists and contributes to disease progression, motivating the development of anti-inflammatory adjuncts alongside disease-modifying interventions.
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