Niksa Kastrapeli on Muck Rack

Niksa Kastrapeli

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Articles

Peptide occupancy governs HLA-E checkpoint interactions enabling VISTA recognition of destabilized HLA-E conformers

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By Soroush Ghaffari, Michael Donkor, Katherine Upchurch-Ange, Susanne Gimlin, Jon A. Weidanz, Chelsae R. Watters, Carly Wilder, Gizem Oter, Niksa Kastrapeli
| Nature Verified
Abstract Human leukocyte antigen E (HLA-E) plays a central role in immune regulation across homeostasis, infection, cancer, and transplantation. Canonically, HLA-E presents leader sequence-derived VL9 peptides to engage CD94/NKG2 receptors, while alternative peptides disrupt this interaction. HLA-E also interacts with LILRB1/2 and the checkpoint molecule VISTA, but the role of peptide occupancy in these interactions remains unclear.
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