Nila van Overbeek on Muck Rack

Nila van Overbeek

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Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates - Nature Communications

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By Fredrik Trulsson, Vyacheslav Akimov, Jürgen Cox, Girish M. Shah, Nila van Overbeek
| Nature
Abstract The ubiquitin-proteasome axis has been extensively explored at a system-wide level, but the impact of deubiquitinating enzymes (DUBs) on the ubiquitinome remains largely unknown. Here, we compare the contributions of the proteasome and DUBs on the global ubiquitinome, using UbiSite technology, inhibitors and mass spectrometry.
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