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Nilambari Pawar on Muck Rack

Nilambari Pawar

As seen in: Nature
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Articles

Functional prediction of immune checkpoint inhibitor response in renal cell carcinoma using a zebrafish patient-derived xenograft platform

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By Jin-Sung Chung, Lei Guo, Nicholas S. Bingham, Alana L. Christie, Vitaly Margulis, Lin Xu, Ponciano D. Jr, Hans J. Hammers, Kiyoshi Ariizumi, Nilambari Pawar
| Nature Verified
Abstract To predict individual patient responses to immune checkpoint inhibitors (ICIs), we developed a biologic assay for renal cell carcinoma (RCC) in which whole tumor cells (WTCs) isolated from patients are mixed ex vivo with nivolumab or control IgG and injected into zebrafish larvae (zPDX). ICI response is quantified as the percentage reduction in tumor size relative to control treatment.
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