Nilson N. Mendes Neto

Chronic pain often coincides with treatment-resistant depression, and can be a major contributor to antidepressant failure, but is seldom taken into account. In this Comment, we suggest ways of incorporating pain measurement and management into the care of people with this form of depression.

To the Editor Shi and colleagues1 provide important nationally representative data showing that parent-reported chronic pain is more than twice as prevalent in US children with developmental disabilities (13.2%) than in those without (5.5%), with the strongest associations observed in cerebral palsy and seizure disorders. The study also highlights the amplifying role of lower family income, lower parental education, and adverse childhood experiences.

Youth suicide has become one of the most urgent and complex public health crises in the US. Suicide rates among individuals aged 10 to 19 years have risen over the past 2 decades, driven by interacting developmental, social, and structural forces that are not easily amenable to single-component solutions.